Objective : To study whether there is a relation between the application of corticosteroids\nand occurrence of postmenopausal bleeding. Also we want to determine\nwhether corticosteroids can cause an irregularity in a previously regular\nmenstruation cycle. Design and Setting : Prospective cohort study in the\ndepartment of anesthesiology. Patients : 209 women who received a single dosage\nof corticosteroids as treatment for pain. Interventions : None, observational\ncohort study; all women received standard care. Main outcome measures\n: Postmenopausal blood loss or disruption of menstruation cycle. Result :\nPostmenopausal blood loss or disruption of menstruation cycle were both\nmore common 6 weeks after administration of corticosteroids, but were\nsometimes also reported 2 weeks after administration of corticosteroids. Conclusion\n: After administration of corticosteroids in a postmenopausal woman\nan episode of menstruation like bleeding can be expected. This is probably\ndue to a transient drop of androstenedione. In premenopausal women a transient\nchange in menstruation cycle can be observed.
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